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human PIAS1 shRNA silencing AAV

Name 
AAV-h-PIAS1-shRNA
Cat No 
shAAV-218884
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PIAS1.

shAAV-218884
AAV-h-PIAS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PIAS1 (protein inhibitor of activated STAT 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DDXBP1; GBP; GU/RH-II; ZMIZ3
Description (Vector)
PIAS1 encodes a member of the mammalian PIAS (protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)) family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.
Gene ID
8554
Gene Name (Vector)
protein inhibitor of activated STAT 1
Gene Symbol
PIAS1
HGNC ID
HGNC:2752
ORF Size (aa)
1956
ORF Size (bp)
1956 bp
RefSeq ID
NM_016166
RefSeq Synonyms
NM_016166, NM_001320687, BC121797, BC118587,
Species
human
UniGene ID
Hs.162458

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.