human PHOX2A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PHOX2A.
shAAV-218855
AAV-h-PHOX2A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PHOX2A (paired like homeobox 2a). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ARIX; CFEOM2; FEOM2; NCAM2; PMX2A
Description (Vector)
PHOX2A contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.
Gene ID
401
Gene Name (Vector)
paired like homeobox 2a
Gene Symbol
PHOX2A
HGNC ID
HGNC:691
ORF Size (aa)
855
RefSeq ID
NM_005169
RefSeq Synonyms
NM_005169, BC041564,
Species
human
UniGene ID
Hs.707879
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.