human PHIP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PHIP.
shAAV-218828
AAV-h-PHIP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PHIP (pleckstrin homology domain interacting protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BRWD2; DCAF14; DDB1 and CUL4 associated factor 14; DIDOD; IRS-1 PH domain-binding protein; ndrp; PH-interacting protein; PHIP; WD repeat-containing protein 11; WDR11
Description (eCommerce)
PH-interacting protein (PHIP) was isolated as factor that binds to the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS-1). PHIP was determined not to be a substrate of the insulin receptor but may instead serve to link IRS-1 to the insulin receptor. PHIP has also been implicated as a positive regulator of beta-cell mitogenesis and survival.
Description (Vector)
PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 (PubMed 11018022); Podcheko et al., 2007 (PubMed 17636024)).(supplied by OMIM, Jun 2009)
Gene ID
55023
Gene Name (eCommerce)
pleckstrin homology domain interacting protein
Gene Name (Vector)
pleckstrin homology domain interacting protein
Gene Symbol
PHIP
HGNC ID
HGNC:15673
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5466
ORF Size (bp)
5466 bp
Protein Name (eCommerce)
PH-interacting protein
RefSeq ID
NM_017934
RefSeq Synonyms
NM_017934, BC137488, BC008909,
Research Areas
Apoptosis,Cell Cycle,Cytoskeleton,Insulin Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
PH-interacting protein (PHIP) was isolated as factor that binds to the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS-1). PHIP was determined not to be a substrate of the insulin receptor but may instead serve to link IRS-1 to the insulin receptor. PHIP has also been implicated as a positive regulator of beta-cell mitogenesis and survival.
UniGene ID
Hs.606356
UniProt ID (eCommerce)
Q8WWQ0
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.