human PFDN5 shRNA silencing AAV

Name 
AAV-h-PFDN5-shRNA
Cat No 
shAAV-218663
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PFDN5.

shAAV-218663
AAV-h-PFDN5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PFDN5 (prefoldin subunit 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
c-myc binding protein; c-Myc-binding protein Mm-1; MM1; MM-1; Myc modulator 1; myc modulator-1; PFD5; prefoldin subunit 5
Description (eCommerce)
Myc modulator 1 (MM-1) is also known as Prefoldin subunit 5. MM-1 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. MM-1 binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for non-native proteins. MM-1 has been show to represses the transcriptional activity of MYC [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q99471].
Description (Vector)
PFDN5 encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.
Gene ID
5204
Gene Name (eCommerce)
prefoldin subunit 5
Gene Name (Vector)
prefoldin subunit 5
Gene Symbol
PFDN5
HGNC ID
HGNC:8869
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
465
Protein Name (eCommerce)
Prefoldin subunit 5
RefSeq ID
NM_002624
RefSeq Synonyms
NM_145897, NM_002624, BC062671,
Research Areas
Metabolism/Metabolic Process,Protein Folding,Signal Transduction,Transcription Factor/Regulator,Translational Control,Wnt Signaling
Research Areas (Faceted)
cell_biology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
Myc modulator 1 (MM-1) is also known as Prefoldin subunit 5. MM-1 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. MM-1 binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for non-native proteins. MM-1 has been show to represses the transcriptional activity of MYC [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q99471].
UniGene ID
Hs.655327
UniProt ID (eCommerce)
Q99471

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.