human PEX1 shRNA silencing AAV

Name 
AAV-h-PEX1-shRNA
Cat No 
shAAV-218628
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PEX1.

shAAV-218628
AAV-h-PEX1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PEX1 (peroxisomal biogenesis factor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HMLR1; PBD1A; PBD1B; peroxin-1; peroxisome biogenesis disorder protein 1; peroxisome biogenesis factor 1; Zellweger syndrome; ZWS; ZWS1
Description (eCommerce)
Peroxin-1 (PeX1) encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. PEX1 is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis [taken from NCBI Entrez Gene (Gene ID: 5189)].
Description (Vector)
PEX1 encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome.
Gene ID
5189
Gene Name (eCommerce)
peroxisomal biogenesis factor 1
Gene Name (Vector)
peroxisomal biogenesis factor 1
Gene Symbol
PEX1
HGNC ID
HGNC:8850
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3852
ORF Size (bp)
3852 bp
Protein Name (eCommerce)
Peroxisome biogenesis factor 1
RefSeq ID
NM_000466
RefSeq Synonyms
NM_001282678, NM_001282677, NM_000466, BC035575,
Research Areas
Neurobiology
Research Areas (Faceted)
neurobiology
Species
human
Target Sentence
Peroxin-1 (PeX1) encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. PEX1 is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis [taken from NCBI Entrez Gene (Gene ID: 5189)].
UniGene ID
Hs.164682
UniProt ID (eCommerce)
O43933

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.