human PDIA6 shRNA silencing AAV

Name 
AAV-h-PDIA6-shRNA
Cat No 
shAAV-218530
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PDIA6.

shAAV-218530
AAV-h-PDIA6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDIA6 (protein disulfide isomerase family A member 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
endoplasmic reticulum protein 5; epididymis secretory sperm binding protein; ER protein 5; ERP5; P5; protein disulfide isomerase P5; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; protein disulfide-isomerase A6; thioredoxin domain containing 7 (protein disulfide isomerase); thioredoxin domain-containing protein 7; TXNDC7
Description (eCommerce)
Endoplasmic reticulum protein 5 (ERp5) may function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15084].
Description (Vector)
Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 (PubMed 7590364)).(supplied by OMIM, Mar 2008)
Gene ID
10130
Gene Name (eCommerce)
protein disulfide isomerase family A member 6
Gene Name (Vector)
protein disulfide isomerase family A member 6
Gene Symbol
PDIA6
HGNC ID
HGNC:30168
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1323
ORF Size (bp)
1323 bp
Protein Name (eCommerce)
Protein disulfide-isomerase A6
RefSeq ID
NM_005742
RefSeq Synonyms
NM_005742, NM_001282707, NM_001282706, NM_001282705, NM_001282704, BC001312,
Research Areas
Golgi Apparatus,Metabolism/Metabolic Process,Protein Folding,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,metabolism
Species
human
Target Sentence
Endoplasmic reticulum protein 5 (ERp5) may function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15084].
UniGene ID
Hs.212102
UniProt ID (eCommerce)
Q15084

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.