human PDIA3 shRNA silencing AAV

Name 
AAV-h-PDIA3-shRNA
Cat No 
shAAV-218522
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PDIA3.

shAAV-218522
AAV-h-PDIA3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDIA3 (protein disulfide isomerase family A member 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
58 kDa glucose-regulated protein; 58 kDa microsomal protein; disulfide isomerase ER-60; endoplasmic reticulum P58; endoplasmic reticulum resident protein 57; endoplasmic reticulum resident protein 60; epididymis secretory protein Li 269; epididymis secretory sperm binding protein Li 93n; ER protein 57; ER protein 60; ER60; ERp57; ERp60; ERp61; glucose regulated protein, 58kDa; GRP57; GRP58; HEL-S-269; HEL-S-93n; HsT17083; P58; phospholipase C-alpha; PI-PLC; protein disulfide isomerase-associated 3; protein disulfide-isomerase A3
Description (eCommerce)
Protein disulfide-isomerase A3 (PDIA3) catalyzes the rearrangement of -S-S- bonds in proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P30101].
Description (Vector)
PDIA3 encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
Gene ID
2923
Gene Name (eCommerce)
protein disulfide isomerase family A member 3
Gene Name (Vector)
protein disulfide isomerase family A member 3
Gene Symbol
PDIA3
HGNC ID
HGNC:4606
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1518
ORF Size (bp)
1518 bp
Protein Name (eCommerce)
Protein disulfide-isomerase A3
RefSeq ID
NM_005313
RefSeq Synonyms
NM_005313, BC071878, BC036000, BC014433,
Research Areas
Antigen Processing and Presentation,Apoptosis,Immunology,Metabolism/Metabolic Process,Protein Folding,Signal Transduction,Translational Control
Research Areas (Faceted)
cell_biology,immunology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
Protein disulfide-isomerase A3 (PDIA3) catalyzes the rearrangement of -S-S- bonds in proteins [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P30101].
UniGene ID
Hs.712781
UniProt ID (eCommerce)
P30101

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.