human PDE6H shRNA silencing AAV

Name
AAV-h-PDE6H-shRNA

Cat No
shAAV-218487

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human PDE6H.

shAAV-218487

AAV-h-PDE6H-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDE6H (phosphodiesterase 6H). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACHM6; RCD3

Description (Vector)

PDE6H encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).

Gene ID

5149

Gene Name (Vector)

phosphodiesterase 6H

Gene Symbol

PDE6H

HGNC ID

HGNC:8790

ORF Size (aa)

252

RefSeq ID

NM_006205

RefSeq Synonyms

NM_006205, BC093740, BC093738, BC069800, BC069774,

Species

human

UniGene ID

Hs.54471

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.