human PDE4A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PDE4A.
shAAV-218474
AAV-h-PDE4A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PDE4A (phosphodiesterase 4A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DPDE2; PDE4; PDE46
Description (Vector)
PDE4A belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
5141
Gene Name (Vector)
phosphodiesterase 4A
Gene Symbol
PDE4A
HGNC ID
HGNC:8780
ORF Size (aa)
1944
ORF Size (bp)
1944 bp
RefSeq ID
NM_006202
RefSeq Synonyms
NM_006202, NM_001243121, NM_001111309, NM_001111308, NM_001111307, BC038234, BC019864,
Species
human
UniGene ID
Hs.89901
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.