human PDCL shRNA silencing AAV

Name 
AAV-h-PDCL-shRNA
Cat No 
shAAV-218449
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PDCL.

shAAV-218449
AAV-h-PDCL-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDCL (phosducin like). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PhLP; phosducin-like protein
Description (eCommerce)
Phosducin-like protein (PDCL) is a putative modulator of heterotrimeric G proteins. PDCL shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins [taken from NCBI Entrez Gene (Gene ID: 5082)].
Description (Vector)
Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.
Gene ID
5082
Gene Name (eCommerce)
phosducin like
Gene Name (Vector)
phosducin like
Gene Symbol
PDCL
HGNC ID
HGNC:8770
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
906
Protein Name (eCommerce)
Phosducin-like protein
RefSeq ID
NM_005388
RefSeq Synonyms
NM_005388, BC017227,
Research Areas
Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology
Species
human
Target Sentence
Phosducin-like protein (PDCL) is a putative modulator of heterotrimeric G proteins. PDCL shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins [taken from NCBI Entrez Gene (Gene ID: 5082)].
UniGene ID
Hs.620774
UniProt ID (eCommerce)
Q13371

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.