human PDCD11 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PDCD11.
shAAV-218435
AAV-h-PDCD11-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PDCD11 (programmed cell death 11). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ALG4; ALG-4; apoptosis-linked gene 4; NFBP; NF-kappa-B-binding protein; programmed cell death protein 11; protein RRP5 homolog; RRP5
Description (eCommerce)
Programmed cell death 11 (PDCD11) is essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA and may be involved in the biogenesis of rRNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14690].
Description (Vector)
PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 (PubMed 14624448); Sweet et al., 2008 (PubMed 17654514)).(supplied by OMIM, Oct 2008)
Gene ID
22984
Gene Name (eCommerce)
programmed cell death 11
Gene Name (Vector)
programmed cell death 11
Gene Symbol
PDCD11
HGNC ID
HGNC:13408
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5616
ORF Size (bp)
5616 bp
Protein Name (eCommerce)
Protein RRP5 homolog
RefSeq ID
NM_014976
RefSeq Synonyms
NM_014976, BC172442,
Research Areas
mRNA Processing,RNA Binding,RNA Processing,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Programmed cell death 11 (PDCD11) is essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA and may be involved in the biogenesis of rRNA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q14690].
UniGene ID
Hs.239499
UniProt ID (eCommerce)
Q14690
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.