human PCDHB15 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PCDHB15.
shAAV-218350
AAV-h-PCDHB15-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PCDHB15 (protocadherin beta 15). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PCDH-BETA15
Description (Vector)
PCDHB15 is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.
Gene ID
56121
Gene Name (Vector)
protocadherin beta 15
Gene Symbol
PCDHB15
HGNC ID
HGNC:8686
ORF Size (aa)
2364
ORF Size (bp)
2364 bp
RefSeq ID
NM_018935
RefSeq Synonyms
NM_018935, BC038797,
Species
human
UniGene ID
Hs.130757
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.