human PATL1 shRNA silencing AAV

Name
AAV-h-PATL1-shRNA

Cat No
shAAV-218263

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PATL1.

shAAV-218263

AAV-h-PATL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PATL1 (PAT1 homolog 1, processing body mRNA decay factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

hPat1b; Pat1b; PAT1-like protein 1; protein associated with topoisomerase II homolog 1; protein PAT1 homolog 1; protein PAT1 homolog b

Description (eCommerce)

Pat1 homolog b (Pat1b) is an RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Pat1b acts as a scaffold protein that connects deadenylation and decapping machinery. Pat1b is required for cytoplasmic mRNA processing body (P-body) assembly, and in cases of infection, it is required for translation and replication of hepatitis C virus (HCV) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q86TB9].

Gene ID

219988

Gene Name (eCommerce)

PAT1 homolog 1, processing body mRNA decay factor

Gene Name (Vector)

PAT1 homolog 1, processing body mRNA decay factor

Gene Symbol

PATL1

HGNC ID

HGNC:26721

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1884

ORF Size (bp)

1884 bp

Protein Name (eCommerce)

Protein PAT1 homolog 1

RefSeq ID

NM_152716

RefSeq Synonyms

NM_152716, BC109039, BC109038, BC065264,

Research Areas

Gene Expression,RNA Binding,RNA Processing

Research Areas (Faceted)

cell_biology,genetics,transcription_translation

Species

human

Target Sentence

Pat1 homolog b (Pat1b) is an RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Pat1b acts as a scaffold protein that connects deadenylation and decapping machinery. Pat1b is required for cytoplasmic mRNA processing body (P-body) assembly, and in cases of infection, it is required for translation and replication of hepatitis C virus (HCV) [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q86TB9].

UniGene ID

Hs.591960

UniProt ID (eCommerce)

Q86TB9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.