human PANK1 shRNA silencing AAV

Name
AAV-h-PANK1-shRNA

Cat No
shAAV-218175

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PANK1.

shAAV-218175

AAV-h-PANK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PANK1 (pantothenate kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PANK

Description (Vector)

PANK1 encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. PANK1 and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636).

Gene ID

53354

Gene Name (Vector)

pantothenate kinase 1

Gene Symbol

PANK1

HGNC ID

HGNC:8598

ORF Size (aa)

1797

ORF Size (bp)

1797 bp

RefSeq ID

NM_138316

RefSeq Synonyms

NM_148978, NM_148977, NM_138316, BC172476, BC156381, BC026296,

Species

human

UniGene ID

Hs.715502

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.