human AKAP2 shRNA silencing AAV

Name
AAV-h-AKAP2-shRNA

Cat No
shAAV-218165

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human AKAP2.

shAAV-218165

AAV-h-AKAP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human AKAP2 (A-kinase anchoring protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

A kinase (PRKA) anchor protein 2; AKAP-2; AKAPKL; AKAP-KL; A-kinase anchor protein 2; MISP2; PRKA2; protein kinase A anchoring protein 2; protein kinase A2; Protein kinase A-anchoring protein 2

Description (eCommerce)

AKAP2 (A-kinase anchoring protein 2) was identified in a yeast two-hybrid screen as a protein that interacts with protein kinase A (PKA). AKAP2 functions to direct the subcellular localization of PKA and may also function as a link for cytoskeletal signaling complexes. Structurally, AKAP2 contains two tandem RGS domains, a PKA-binding motif, and a PDZ (PSD95/Dlg/ZO1)-binding motif.

Description (Vector)

AKAP2 binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene.

Gene ID

11217

Gene Name (eCommerce)

A-kinase anchoring protein 2

Gene Name (Vector)

A-kinase anchoring protein 2

Gene Symbol

AKAP2

HGNC ID

HGNC:372

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2847

ORF Size (bp)

2847 bp

Protein Name (eCommerce)

A-kinase anchor protein 2

RefSeq ID

NM_001004065

RefSeq Synonyms

NM_001198656, NM_001136562, NM_001004065, BC171800, BC146863,

Research Areas

Signal Transduction

Research Areas (Faceted)

signal_transduction

Species

human

Target Sentence

AKAP2 (A-kinase anchoring protein 2) was identified in a yeast two-hybrid screen as a protein that interacts with protein kinase A (PKA). AKAP2 functions to direct the subcellular localization of PKA and may also function as a link for cytoskeletal signaling complexes. Structurally, AKAP2 contains two tandem RGS domains, a PKA-binding motif, and a PDZ (PSD95/Dlg/ZO1)-binding motif.

UniGene ID

Hs.591908

UniProt ID (eCommerce)

Q9Y2D5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.