human PADI2 shRNA silencing AAV

Cat. No: shAAV-218114

Availability: 6-8 weeks

Name: AAV-h-PADI2-shRNA

This is an AAV expressing shRNA for silencing of Human PADI2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PADI2
Gene Name: peptidyl arginine deiminase 2
Gene ID: 11240
Gene Synonyms: PAD-H19; PAD2; PDI2
ORF Size: 1314 bp
RefSeq#: NM_007365
Gene Description: PADI2 encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. PADI2 exists in a cluster with four other paralogous genes.
UniGene ID: Hs.33455
HGNC ID: HGNC:18341