human PACS1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PACS1.
shAAV-218104
AAV-h-PACS1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PACS1 (phosphofurin acidic cluster sorting protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MRD17; SHMS
Description (Vector)
PACS1 encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.
Gene ID
55690
Gene Name (Vector)
phosphofurin acidic cluster sorting protein 1
Gene Symbol
PACS1
HGNC ID
HGNC:30032
ORF Size (aa)
2892
ORF Size (bp)
2892 bp
RefSeq ID
NM_018026
RefSeq Synonyms
NM_018026, BC052577, BC010096,
Species
human
UniGene ID
Hs.644326
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.