human P4HA2 shRNA silencing AAV

Cat. No: shAAV-218077

Availability: 4-5 weeks

Name: AAV-h-P4HA2-shRNA

This is an AAV expressing shRNA for silencing of Human P4HA2.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: P4HA2
Gene Name: prolyl 4-hydroxylase, alpha polypeptide II
Gene ID: 8974
Gene Synonyms: EEK; EK3; HEK3; KIAA1459;
ORF Size: 1602 bp
RefSeq#: NM_004199
Gene Description: P4HA2 encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.
UniGene ID: Hs.519568
HGNC ID: HGNC:8547