human OTUB1 shRNA silencing AAV

Name 
AAV-h-OTUB1-shRNA
Cat No 
shAAV-217996
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human OTUB1.

shAAV-217996
AAV-h-OTUB1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
deubiquitinating enzyme OTUB1; hOTU1; HSPC263; OTB1; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU1; otubain-1; OTU-domain Ubal-binding 1; ubiquitin thioesterase OTUB1; ubiquitin-specific protease otubain 1; ubiquitin-specific-processing protease OTUB1
Description (eCommerce)
OTUB1 (OTU domain, ubiquitin aldehyde binding 1) is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth [taken from NCBI Entrez Gene (Gene ID: 55611].
Description (Vector)
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.
Gene ID
55611
Gene Name (eCommerce)
OTU deubiquitinase, ubiquitin aldehyde binding 1
Gene Name (Vector)
OTU deubiquitinase, ubiquitin aldehyde binding 1
Gene Symbol
OTUB1
HGNC ID
HGNC:23077
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
816
Protein Name (eCommerce)
Ubiquitin thioesterase OTUB1
RefSeq ID
NM_017670
RefSeq Synonyms
NM_017670, BC107701, BC010368, BC007519,
Research Areas
DNA Damage/Repair,Histone Modification,Immunology,Ubiquitination
Research Areas (Faceted)
cell_biology,genetics,immunology,transcription_translation
Species
human
Target Sentence
OTUB1 (OTU domain, ubiquitin aldehyde binding 1) is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth [taken from NCBI Entrez Gene (Gene ID: 55611].
UniGene ID
Hs.473788
UniProt ID (eCommerce)
Q96FW1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.