human NUPL2 shRNA silencing AAV

Name
AAV-h-NUPL2-shRNA

Cat No
shAAV-217266

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NUPL2.

shAAV-217266

AAV-h-NUPL2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NUPL2 (nucleoporin like 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CG1; H_RG271G13.9; hCG1; NLP_1; NLP-1; nucleoporin hCG1; nucleoporin-like protein 1; nucleoporin-like protein 2; NUP42 homolog

Description (eCommerce)

Nucleoporin-like protein 2 (NUPL2) is required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelopeÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O15504].

Gene ID

11097

Gene Name (eCommerce)

nucleoporin like 2

Gene Name (Vector)

nucleoporin like 2

Gene Symbol

NUPL2

HGNC ID

HGNC:17010

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1272

ORF Size (bp)

1272 bp

Protein Name (eCommerce)

Nucleoporin-like protein 2

RefSeq ID

NM_007342

RefSeq Synonyms

NM_007342, BC107583, BC005327,

Research Areas

Cell Cycle,Gene Expression,Host-Virus Interactions,Immunology,Metabolism/Metabolic Process,mRNA Processing,mRNA Transport,Ribonucleoprotein Transport,RNA Processing,RNA Transport,Zinc-finger

Research Areas (Faceted)

cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,immunology,metabolism

Species

human

Target Sentence

Nucleoporin-like protein 2 (NUPL2) is required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelopeÂ [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O15504].

UniGene ID

Hs.408241

UniProt ID (eCommerce)

O15504

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.