human NUP214 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NUP214.
shAAV-217243
AAV-h-NUP214-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NUP214 (nucleoporin 214). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
214 kDa nucleoporin; CAIN; CAN; CAN protein, putative oncogene; nuclear pore complex protein Nup214; nucleoporin 214kDa; Nucleoporin Nup214; Protein CAN
Description (eCommerce)
Nucleoporins are the main components of the nuclear pore complex that provides a conduit across the nuclear envelope for the transport of macromolecules between the nucleus and cytoplasm. Nucleoporin 214 (NUP214) is required for CRM1-mediated nuclear protein export as well as cell cycle progression.
Description (Vector)
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome.
Gene ID
8021
Gene Name (eCommerce)
nucleoporin 214
Gene Name (Vector)
nucleoporin 214
Gene Symbol
NUP214
HGNC ID
HGNC:8064
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6273
ORF Size (bp)
6273 bp
Protein Name (eCommerce)
Nuclear pore complex protein Nup214
RefSeq ID
NM_005085
RefSeq Synonyms
NM_005085, NM_001318325, NM_001318324, BC105998, BC045620,
Research Areas
Cancer,Cell Cycle,Gene Expression,Host-Virus Interactions,Immunology,Metabolism/Metabolic Process,MicroRNAs in Cancer,mRNA Binding,mRNA Processing,mRNA Transport,NFAT Signaling,Nuclear Import/Export,Ribonucleoprotein Transport,RNA Processing,RNA Transport,Signal Transduction,TGF-beta Signaling,Transport,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,genetics,signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease,immunology,metabolism,genetics,transcription_translation,cell_biology,signal_transduction,cell_biology,genetics,transcription_translation,cell_biology,signal_transduction,immunology,cell_biology,cancer,transcription_translation
Species
human
Target Sentence
Nucleoporins are the main components of the nuclear pore complex that provides a conduit across the nuclear envelope for the transport of macromolecules between the nucleus and cytoplasm. Nucleoporin 214 (NUP214) is required for CRM1-mediated nuclear protein export as well as cell cycle progression.
UniGene ID
Hs.654530
UniProt ID (eCommerce)
P35658
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.