human NSUN5 shRNA silencing AAV

Name
AAV-h-NSUN5-shRNA

Cat No
shAAV-217123

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NSUN5.

shAAV-217123

AAV-h-NSUN5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NSUN5 (NOP2/Sun RNA methyltransferase family member 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NOL1; NOL1R; NSUN5A; p120; p120(NOL1); WBSCR20; WBSCR20A

Description (Vector)

NSUN5 encodes a member of the evolutionarily conserved NOL1/NOP2/Sun domain family. The encoded protein may function as a DNA methyltransferase in the nucleus. NSUN5 is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Gene ID

55695

Gene Name (Vector)

NOP2/Sun RNA methyltransferase family member 5

Gene Symbol

NSUN5

HGNC ID

HGNC:16385

ORF Size (aa)

1401

ORF Size (bp)

1401 bp

RefSeq ID

NM_018044

RefSeq Synonyms

NM_148956, NM_018044, NM_001168348, NM_001168347, BC008084,

Species

human

UniGene ID

Hs.647060

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.