human NRCAM shRNA silencing AAV

Name
AAV-h-NRCAM-shRNA

Cat No
shAAV-217072

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NRCAM.

shAAV-217072

AAV-h-NRCAM-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NRCAM (neuronal cell adhesion molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

4897

Gene Name (Vector)

neuronal cell adhesion molecule

Gene Symbol

NRCAM

HGNC ID

HGNC:7994

ORF Size (aa)

3543

ORF Size (bp)

3543 bp

RefSeq ID

NM_005010

RefSeq Synonyms

NM_005010, NM_001193584, NM_001193583, NM_001193582, NM_001037132, BC115736, BC114570, BC098401,

Species

human

UniGene ID

Hs.21422

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.