human NR1H3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NR1H3.
shAAV-217036
AAV-h-NR1H3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NR1H3 (nuclear receptor subfamily 1 group H member 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LXR-a; LXRA; RLD-1
Description (Vector)
NR1H3 belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
10062
Gene Name (Vector)
nuclear receptor subfamily 1 group H member 3
Gene Symbol
NR1H3
HGNC ID
HGNC:7966
ORF Size (aa)
1209
ORF Size (bp)
1209 bp
RefSeq ID
NM_005693
RefSeq Synonyms
NM_005693, NM_001251935, NM_001251934, NM_001130102, NM_001130101, BC041172, BC008819,
Species
human
UniGene ID
Hs.438863
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.