human NR1H2 shRNA silencing AAV

Name
AAV-h-NR1H2-shRNA

Cat No
shAAV-217031

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NR1H2.

shAAV-217031

AAV-h-NR1H2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NR1H2 (nuclear receptor subfamily 1 group H member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LXR-b; LXRB; NER; NER-I; RIP15; UNR

Description (Vector)

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 (PubMed 19436111)).(supplied by OMIM, Jan 2010)

Gene ID

7376

Gene Name (Vector)

nuclear receptor subfamily 1 group H member 2

Gene Symbol

NR1H2

HGNC ID

HGNC:7965

ORF Size (aa)

1386

ORF Size (bp)

1386 bp

RefSeq ID

NM_007121

RefSeq Synonyms

NM_007121, NM_001256647, BC074500, BC047750, BC033500, BC007790,

Species

human

UniGene ID

Hs.432976

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.