human NPR2 shRNA silencing AAV

Name
AAV-h-NPR2-shRNA

Cat No
shAAV-216998

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NPR2.

shAAV-216998

AAV-h-NPR2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NPR2 (natriuretic peptide receptor 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AMDM; ANPb; ANPRB; ECDM; GUC2B; GUCY2B; NPRB; NPRBi; SNSK

Description (Vector)

NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Gene ID

4882

Gene Name (Vector)

natriuretic peptide receptor 2

Gene Symbol

NPR2

HGNC ID

HGNC:7944

ORF Size (aa)

3144

ORF Size (bp)

3144 bp

RefSeq ID

NM_003995

RefSeq Synonyms

NM_003995, BC166642,

Species

human

UniGene ID

Hs.78518

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.