human NPPB shRNA silencing AAV

Name
AAV-h-NPPB-shRNA

Cat No
shAAV-216993

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NPPB.

shAAV-216993

AAV-h-NPPB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NPPB (natriuretic peptide B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BNP

Description (Vector)

NPPB is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis.

Gene ID

4879

Gene Name (Vector)

natriuretic peptide B

Gene Symbol

NPPB

HGNC ID

HGNC:7940

ORF Size (aa)

405

RefSeq ID

NM_002521

RefSeq Synonyms

NM_002521, BC025785,

Species

human

UniGene ID

Hs.219140

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.