human NPL2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human HOGA1.
shAAV-216973
AAV-h-NPL2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human HOGA1 (4-hydroxy-2-oxoglutarate aldolase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C10orf65; DHDPS2; DHDPSL; HP3; NPL2
Description (Vector)
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
112817
Gene Name (Vector)
4-hydroxy-2-oxoglutarate aldolase 1
Gene Symbol
HOGA1
HGNC ID
HGNC:25155
ORF Size (aa)
984
RefSeq ID
NM_138413
RefSeq Synonyms
NM_138413, NM_001134670, BC057821, BC045550, BC011916,
Species
human
UniGene ID
Hs.180346
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.