human NOSTRIN shRNA silencing AAV

Name
AAV-h-NOSTRIN-shRNA

Cat No
shAAV-216912

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NOSTRIN.

shAAV-216912

AAV-h-NOSTRIN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NOSTRIN (nitric oxide synthase trafficking). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DaIP2

Description (Vector)

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.(supplied by OMIM, Apr 2004)

Gene ID

115677

Gene Name (Vector)

nitric oxide synthase trafficking

Gene Symbol

NOSTRIN

HGNC ID

HGNC:20203

ORF Size (aa)

1287

ORF Size (bp)

1287 bp

RefSeq ID

NM_052946

RefSeq Synonyms

NM_052946, NM_001171632, NM_001171631, NM_001039724, BC093072, BC014189,

Species

human

UniGene ID

Hs.189780

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.