human NOS1AP shRNA silencing AAV

Name
AAV-h-NOS1AP-shRNA

Cat No
shAAV-216903

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NOS1AP.

shAAV-216903

AAV-h-NOS1AP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NOS1AP (nitric oxide synthase 1 adaptor protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

6330408P19Rik; CAPON

Description (Vector)

NOS1AP encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

9722

Gene Name (Vector)

nitric oxide synthase 1 adaptor protein

Gene Symbol

NOS1AP

HGNC ID

HGNC:16859

ORF Size (aa)

1521

ORF Size (bp)

1521 bp

RefSeq ID

NM_014697

RefSeq Synonyms

NM_014697, NM_001164757, NM_001126060, BC118499, BC112295, BC111928,

Species

human

UniGene ID

Hs.655000

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.