human NOD2 shRNA silencing AAV

Name
AAV-h-NOD2-shRNA

Cat No
shAAV-216856

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NOD2.

shAAV-216856

AAV-h-NOD2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NOD2 (nucleotide binding oligomerization domain containing 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACUG; BLAU; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1

Description (Vector)

NOD2 is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.

Gene ID

64127

Gene Name (Vector)

nucleotide binding oligomerization domain containing 2

Gene Symbol

NOD2

HGNC ID

HGNC:5331

ORF Size (aa)

3123

ORF Size (bp)

3123 bp

RefSeq ID

NM_022162

RefSeq Synonyms

NM_022162, NM_001293557, BC156571, BC152737,

Species

human

UniGene ID

Hs.592072

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.