human NMI shRNA silencing AAV

Name 
AAV-h-NMI-shRNA
Cat No 
shAAV-216826
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NMI.

shAAV-216826
AAV-h-NMI-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NMI (N-myc and STAT interactor). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Nmi; N-myc and STAT interactor; N-myc-interactor
Description (eCommerce)
N-Myc Interactor (NMI) was identified as a protein that interacts with N-Myc and C-Myc transcription factors as well as the STAT (Signal Transducers and Activators of Transcription) family of transcription factors. NMI has also been found to be a component of a transcription complex with BRCA1 and c-Myc; the complex functions to inhibit human telomerase reverse transcriptase (hTERT) gene transcription.
Description (Vector)
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
Gene ID
9111
Gene Name (eCommerce)
N-myc and STAT interactor
Gene Name (Vector)
N-myc and STAT interactor
Gene Symbol
NMI
HGNC ID
HGNC:7854
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
924
ORF Size (bp)
924 bp
Protein Name (eCommerce)
N-myc-interactor
RefSeq ID
NM_004688
RefSeq Synonyms
NM_004688, BC021987, BC001268,
Research Areas
Cancer,Immunology,Interleukin Signaling,JAK-STAT Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
N-Myc Interactor (NMI) was identified as a protein that interacts with N-Myc and C-Myc transcription factors as well as the STAT (Signal Transducers and Activators of Transcription) family of transcription factors. NMI has also been found to be a component of a transcription complex with BRCA1 and c-Myc; the complex functions to inhibit human telomerase reverse transcriptase (hTERT) gene transcription.
UniGene ID
Hs.54483
UniProt ID (eCommerce)
Q13287

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.