human NLRP7 shRNA silencing AAV

Name
AAV-h-NLRP7-shRNA

Cat No
shAAV-216807

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NLRP7.

shAAV-216807

AAV-h-NLRP7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NLRP7 (NLR family pyrin domain containing 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3

Description (Vector)

NLRP7 encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. NLRP7 may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

199713

Gene Name (Vector)

NLR family pyrin domain containing 7

Gene Symbol

NLRP7

HGNC ID

HGNC:22947

ORF Size (aa)

2892

ORF Size (bp)

2892 bp

RefSeq ID

NM_139176

RefSeq Synonyms

NM_206828, NM_139176, NM_001127255, BC109125, BC109124,

Species

human

UniGene ID

Hs.351118

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.