human NLRP10 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NLRP10.
shAAV-216791
AAV-h-NLRP10-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NLRP10 (NLR family pyrin domain containing 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CLR11.1; NALP10; NOD8; PAN5; PYNOD
Description (Vector)
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.
Gene ID
338322
Gene Name (Vector)
NLR family pyrin domain containing 10
Gene Symbol
NLRP10
HGNC ID
HGNC:21464
ORF Size (aa)
1968
ORF Size (bp)
1968 bp
RefSeq ID
NM_176821
RefSeq Synonyms
NM_176821, BC104957,
Species
human
UniGene ID
Hs.449636
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.