human NKX2-1 shRNA silencing AAV

Name
AAV-h-NKX2-1-shRNA

Cat No
shAAV-216761

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NKX2-1.

shAAV-216761

AAV-h-NKX2-1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NKX2-1 (NK2 homeobox 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BCH; BHC; NK-2; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1

Description (Vector)

NKX2-1 encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. NKX2-1 shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.

Gene ID

7080

Gene Name (Vector)

NK2 homeobox 1

Gene Symbol

NKX2-1

HGNC ID

HGNC:11825

ORF Size (aa)

1116

ORF Size (bp)

1116 bp

RefSeq ID

NM_003317

RefSeq Synonyms

NM_003317, NM_001079668, BC006221,

Species

human

UniGene ID

Hs.94367

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.