human NKAP shRNA silencing AAV

Name
AAV-h-NKAP-shRNA

Cat No
shAAV-216745

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NKAP.

shAAV-216745

AAV-h-NKAP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NKAP (NFKB activating protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

NKAP encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6.

Gene ID

79576

Gene Name (Vector)

NFKB activating protein

Gene Symbol

NKAP

HGNC ID

HGNC:29873

ORF Size (aa)

1248

ORF Size (bp)

1248 bp

RefSeq ID

NM_024528

RefSeq Synonyms

NM_024528, BC032442, BC015354,

Species

human

UniGene ID

Hs.522771

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.