human NHP2 shRNA silencing AAV

Name
AAV-h-NHP2-shRNA

Cat No
shAAV-216695

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NHP2.

shAAV-216695

AAV-h-NHP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NHP2 (NHP2 ribonucleoprotein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DKCB2; NHP2P; NOLA2

Description (Vector)

NHP2 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. NHP2 encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants.

Gene ID

55651

Gene Name (Vector)

NHP2 ribonucleoprotein

Gene Symbol

NHP2

HGNC ID

HGNC:14377

ORF Size (aa)

462

RefSeq ID

NM_017838

RefSeq Synonyms

NM_017838, NM_001034833, BC006387, BC000009,

Species

human

UniGene ID

Hs.27222

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.