human NHP2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NHP2.
shAAV-216695
AAV-h-NHP2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NHP2 (NHP2 ribonucleoprotein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DKCB2; NHP2P; NOLA2
Description (Vector)
NHP2 is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. NHP2 encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants.
Gene ID
55651
Gene Name (Vector)
NHP2 ribonucleoprotein
Gene Symbol
NHP2
HGNC ID
HGNC:14377
ORF Size (aa)
462
RefSeq ID
NM_017838
RefSeq Synonyms
NM_017838, NM_001034833, BC006387, BC000009,
Species
human
UniGene ID
Hs.27222
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.