human NGDN shRNA silencing AAV

Name
AAV-h-NGDN-shRNA

Cat No
shAAV-216670

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NGDN.

shAAV-216670

AAV-h-NGDN-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NGDN (neuroguidin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C14orf120; CANu1; centromere accumulated nuclear protein 1; EIF4E-binding protein; eukaryotic initiation factor 4E and CPEB binding protein; LCP5; lpd-2; neuroguidin; neuroguidin, EIF4E binding protein; NGD

Description (eCommerce)

NGDN is an EIF4E-binding protein that interacts with CPEB and functions as a translational regulatory protein during development of the vertebrate nervous system. [taken from NCBI Entrez Gene (Gene ID: 25983)].

Description (Vector)

Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 (PubMed 16705177)).(supplied by OMIM, Mar 2008)

Gene ID

25983

Gene Name (eCommerce)

neuroguidin

Gene Name (Vector)

neuroguidin

Gene Symbol

NGDN

HGNC ID

HGNC:20271

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

948

ORF Size (bp)

948 bp

Protein Name (eCommerce)

Neuroguidin

RefSeq ID

NM_001042635

RefSeq Synonyms

NM_015514, NM_001042635, BC030817,

Research Areas

Neurobiology,Translational Control

Research Areas (Faceted)

cell_biology,neurobiology,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.9043

UniProt ID (eCommerce)

Q8NEJ9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.