human NFKBIZ shRNA silencing AAV

Name
AAV-h-NFKBIZ-shRNA

Cat No
shAAV-216657

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NFKBIZ.

shAAV-216657

AAV-h-NFKBIZ-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NFKBIZ (NFKB inhibitor zeta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

IKBZ; INAP; MAIL

Description (Vector)

NFKBIZ is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.

Gene ID

64332

Gene Name (Vector)

NFKB inhibitor zeta

Gene Symbol

NFKBIZ

HGNC ID

HGNC:29805

ORF Size (aa)

2157

ORF Size (bp)

2157 bp

RefSeq ID

NM_031419

RefSeq Synonyms

NM_031419, NM_001005474, BC060800,

Species

human

UniGene ID

Hs.319171

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.