human NFAT5 shRNA silencing AAV

Name 
AAV-h-NFAT5-shRNA
Cat No 
shAAV-216627
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NFAT5.

shAAV-216627
AAV-h-NFAT5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NFAT5 (nuclear factor of activated T-cells 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
glutamine rich protein H65; NF-AT5; NFATL1; NFAT-like protein 1; NFAT; Znuclear factor of activated T-cells 5; nuclear factor of activated T-cells 5, tonicity-responsive; OREBP; osmotic response element-binding protein; T-cell transcription factor NFAT5; TonE-binding protein; TONEBP; tonicity-responsive enhancer-binding protein
Description (eCommerce)
The product of the NFAT5 (TONEBP) gene, nuclear factor of activated T-cells 5, is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. NFAT5 regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, NFAT5 exists as a homodimer and forms stable dimers with DNA elements [taken from NCBI Entrez Gene (Gene ID: 10725)].
Description (Vector)
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
10725
Gene Name (eCommerce)
nuclear factor of activated T cells 5
Gene Name (Vector)
nuclear factor of activated T-cells 5
Gene Symbol
NFAT5
HGNC ID
HGNC:7774
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4647
ORF Size (bp)
4647 bp
Protein Name (eCommerce)
Nuclear factor of activated T-cells 5
RefSeq ID
NM_006599
RefSeq Synonyms
NM_173215, NM_173214, NM_138714, NM_138713, NM_006599, NM_001113178, BC146765, BC131509,
Research Areas
Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,signal_transduction,transcription_translation
Species
human
Target Sentence
The product of the NFAT5 (TONEBP) gene, nuclear factor of activated T-cells 5, is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. NFAT5 regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, NFAT5 exists as a homodimer and forms stable dimers with DNA elements [taken from NCBI Entrez Gene (Gene ID: 10725)].
UniGene ID
Hs.371987
UniProt ID (eCommerce)
O94916

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.