human NECAB3 shRNA silencing AAV

Cat. No: shAAV-216543

Availability: 4-5 weeks

Name: AAV-h-NECAB3-shRNA

This is an AAV expressing shRNA for silencing of Human NECAB3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NECAB3
Gene Name: N-terminal EF-hand calcium binding protein 3
Gene ID: 63941
Gene Synonyms: APBA2BP; dJ63M2.4; dJ63M2.5; EFCBP3; NIP1; STIP3; SYTIP2; XB51
ORF Size: 1089 bp
RefSeq#: NM_031231
Gene Description: NECAB3 interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.516986
HGNC ID: HGNC:15851