human NDRG1 shRNA silencing AAV

Name
AAV-h-NDRG1-shRNA

Cat No
shAAV-216456

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NDRG1.

shAAV-216456

AAV-h-NDRG1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NDRG1 (N-myc downstream regulated 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5

Description (Vector)

NDRG1 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

10397

Gene Name (Vector)

N-myc downstream regulated 1

Gene Symbol

NDRG1

HGNC ID

HGNC:7679

ORF Size (aa)

1185

ORF Size (bp)

1185 bp

RefSeq ID

NM_006096

RefSeq Synonyms

NM_006096, NM_001258433, NM_001258432, NM_001135242, BC006260, BC003175,

Species

human

UniGene ID

Hs.372914

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.