human NDE1 shRNA silencing AAV

Name 
AAV-h-NDE1-shRNA
Cat No 
shAAV-216443
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NDE1.

shAAV-216443
AAV-h-NDE1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NDE1 (nudE neurodevelopment protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; HOM-TES-87; LIS1-interacting protein NUDE1, rat homolog; LIS4; MHAC; NDE; nuclear distribution protein nudE homolog 1; NUDE; nudE nuclear distribution E homolog 1; nudE nuclear distribution gene E homolog 1; NUDE1
Description (eCommerce)
NDE1 (nuclear distribution factor E homolog 1) is important to microtubule organization, mitosis, and cell migration. It is required for the duplication of centrosomes and the function of the mitotic spindle. NDE1 is a binding partner of DISC1 (disrupted-in-schizophrenia 1) along with LIS1 (lissencephaly 1) at the centrosome and at synapses in neurons. It is also part of a multiprotein complex that regulates dynein. The NDE1 gene has been identified as a schizophrenia-associated locus.
Description (Vector)
NDE1 encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants.
Gene ID
54820
Gene Name (eCommerce)
nudE neurodevelopment protein 1
Gene Name (Vector)
nudE neurodevelopment protein 1
Gene Symbol
NDE1
HGNC ID
HGNC:17619
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1008
ORF Size (bp)
1008 bp
Protein Name (eCommerce)
Nuclear distribution protein nudE homolog 1
RefSeq ID
NM_017668
RefSeq Synonyms
NM_017668, NM_001143979, BC033900, BC001421,
Research Areas
Cell Cycle,Cell Division,Cytoskeleton,Neurobiology,Neurodevelopment,Neurogenesis
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,neurobiology
Species
human
Target Sentence
NDE1 (nuclear distribution factor E homolog 1) is important to microtubule organization, mitosis, and cell migration. It is required for the duplication of centrosomes and the function of the mitotic spindle. NDE1 is a binding partner of DISC1 (disrupted-in-schizophrenia 1) along with LIS1 (lissencephaly 1) at the centrosome and at synapses in neurons. It is also part of a multiprotein complex that regulates dynein. The NDE1 gene has been identified as a schizophrenia-associated locus.
UniGene ID
Hs.655378
UniProt ID (eCommerce)
Q9NXR1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.