human NBL1 shRNA silencing AAV

Name
AAV-h-NBL1-shRNA

Cat No
shAAV-216363

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NBL1.

shAAV-216363

AAV-h-NBL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NBL1 (neuroblastoma 1, DAN family BMP antagonist). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

D1S1733E; DAN; DAND1; NB; NO3

Description (Vector)

NBL1 product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream chromosome 1 open reading frame 151 locus (GeneID 440574) have been observed.

Gene ID

4681

Gene Name (Vector)

neuroblastoma 1, DAN family BMP antagonist

Gene Symbol

NBL1

HGNC ID

HGNC:7650

ORF Size (aa)

543

RefSeq ID

NM_005380

RefSeq Synonyms

NM_182744, NM_005380, NM_001278166, NM_001278165, NM_001278164, NM_001204086, NM_001204085, NM_001204084, BC012037,

Species

human

UniGene ID

Hs.654502

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.