human NAF1 shRNA silencing AAV

Name 
AAV-h-NAF1-shRNA
Cat No 
shAAV-216287
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NAF1.

shAAV-216287
AAV-h-NAF1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NAF1 (nuclear assembly factor 1 ribonucleoprotein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
H/ACA ribonucleoprotein complex non-core subunit NAF1; hNAF1; nuclear assembly factor 1 homolog
Description (eCommerce)
H/ACA ribonucleoprotein complex non-core subunit NAF1 (nuclear assembly factor 1) is an RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. NAF1 probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96HR8].
Gene ID
92345
Gene Name (eCommerce)
nuclear assembly factor 1 ribonucleoprotein
Gene Name (Vector)
nuclear assembly factor 1 ribonucleoprotein
Gene Symbol
NAF1
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1485
ORF Size (bp)
1485 bp
Protein Name (eCommerce)
H/ACA ribonucleoprotein complex non-core subunit NAF1
RefSeq ID
NM_138386
RefSeq Synonyms
NM_138386, NM_001128931, BC008207,
Research Areas
RNA Binding,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
H/ACA ribonucleoprotein complex non-core subunit NAF1 (nuclear assembly factor 1) is an RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. NAF1 probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96HR8].
UniGene ID
Hs.672113
UniProt ID (eCommerce)
Q96HR8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.