human NAB2 shRNA silencing AAV

Name 
AAV-h-NAB2-shRNA
Cat No 
shAAV-216278
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NAB2.

shAAV-216278
AAV-h-NAB2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NAB2 (NGFI-A binding protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
EGR1 binding protein 2; EGR-1-binding protein 2; MADER; melanoma-associated delayed early response protein; NGFI-A-binding protein 2; Protein MADER
Description (eCommerce)
NGFI-A binding protein 2 (NAB2) is a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex [taken from NCBI Entrez Gene (Gene ID: 4665].
Description (Vector)
NAB2 encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Gene ID
4665
Gene Name (eCommerce)
NGFI-A binding protein 2
Gene Name (Vector)
NGFI-A binding protein 2
Gene Symbol
NAB2
HGNC ID
HGNC:7627
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1578
ORF Size (bp)
1578 bp
Protein Name (eCommerce)
NGFI-A-binding protein 2
RefSeq ID
NM_005967
RefSeq Synonyms
NM_005967, NM_001330305, BC065931, BC007756,
Research Areas
Neurobiology,Neurodevelopment,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology,transcription_translation
Species
human
Target Sentence
NGFI-A binding protein 2 (NAB2) is a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex [taken from NCBI Entrez Gene (Gene ID: 4665].
UniGene ID
Hs.159223
UniProt ID (eCommerce)
Q15742

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.