human N4BP2 shRNA silencing AAV

Name
AAV-h-N4BP2-shRNA

Cat No
shAAV-216264

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human N4BP2.

shAAV-216264

AAV-h-N4BP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human N4BP2 (NEDD4 binding protein 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

B3BP

Description (Vector)

N4BP2 encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination.

Gene ID

55728

Gene Name (Vector)

NEDD4 binding protein 2

Gene Symbol

N4BP2

HGNC ID

HGNC:29851

ORF Size (aa)

5313

ORF Size (bp)

5313 bp

RefSeq ID

NM_018177

RefSeq Synonyms

NM_018177, NM_001318359, BC126466,

Species

human

UniGene ID

Hs.391463

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.