human MYO7A shRNA silencing AAV

Name 
AAV-h-MYO7A-shRNA
Cat No 
shAAV-216223
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MYO7A.

shAAV-216223
AAV-h-MYO7A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MYO7A (myosin VIIA). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DFNA11; DFNB2; MYOVIIA; MYU7A; NSRD2; USH1B
Description (Vector)
MYO7A is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. MYO7A encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants.
Gene ID
4647
Gene Name (Vector)
myosin VIIA
Gene Symbol
MYO7A
HGNC ID
HGNC:7606
ORF Size (aa)
6528
ORF Size (bp)
6528 bp
RefSeq ID
NM_000260
RefSeq Synonyms
NM_001127180, NM_001127179, NM_000260, BC172349,
Species
human
UniGene ID
Hs.370421

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.