human MYO1E shRNA silencing AAV

Name
AAV-h-MYO1E-shRNA

Cat No
shAAV-216212

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human MYO1E.

shAAV-216212

AAV-h-MYO1E-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MYO1E (myosin IE). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FSGS6; HuncM-IC; MYO1C

Description (Vector)

MYO1E encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. MYO1E has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17.

Gene ID

4643

Gene Name (Vector)

myosin IE

Gene Symbol

MYO1E

HGNC ID

HGNC:7599

ORF Size (aa)

3327

ORF Size (bp)

3327 bp

RefSeq ID

NM_004998

RefSeq Synonyms

NM_004998, BC098392,

Species

human

UniGene ID

Hs.654506

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.