human MYH7 shRNA silencing AAV

Name
AAV-h-MYH7-shRNA

Cat No
shAAV-216169

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human MYH7.

shAAV-216169

AAV-h-MYH7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MYH7 (myosin heavy chain 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CMD1S; CMH1; MPD1; MYHCB; SPMD; SPMM

Description (Vector)

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

Gene ID

4625

Gene Name (Vector)

myosin heavy chain 7

Gene Symbol

MYH7

HGNC ID

HGNC:7577

ORF Size (aa)

5808

ORF Size (bp)

5808 bp

RefSeq ID

NM_000257

RefSeq Synonyms

NM_000257, BC112173, BC112171,

Species

human

UniGene ID

Hs.678918

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.